How to Prepare for the ACRP-CCRA Exam: Study Plan, Tips & Resources

1 | Exam Basics

  • Format: 125 multiple-choice questions.
  • Duration: 3 hours.
  • Domains:
    1. Scientific Concepts & Design
    2. Ethical & Participant Safety
    3. Regulatory Requirements
    4. Clinical Trial Operations (GCP)
    5. Study & Site Management
    6. Data Management & Quality
  • Passing: ≈ 70 %
  • Prereq: 3 000 hours of CRA-task experience.

2 | Week-by-Week 8-Week Plan

WeeksFocusKey Tasks
1–2Ethics + GCPRead ICH E6(R2); make flashcards for terms like monitoring plan and source data verification.
3Scientific DesignReview study phases, randomization, risk-based monitoring.
4RegulatorySummarize 21 CFR Parts 50, 54, 56, 312, 812.
5–6Operations + Data QualityRead ICH E8(R1), E9; practice queries and audit trail cases.
7Mock ExamsDo 2× full-length tests under timed conditions.
8Final ReviewRevisit missed topics; sleep and relax before exam day.

3 | Study Materials

  • ACRP Exam Blueprint PDF
  • ICH E6(R2), E8(R1), E9 guidelines
  • FDA CFR Parts 50 & 312
  • ACRP Practice Tests by Clinical Research Exam Prep

4 | Exam-Day Strategy

  • Arrive 30 min early.
  • Read questions slowly — keywords like “best next step.”
  • Use “Flag for Review.”
  • Manage time (~1.5 min per question).
  • Trust first instincts after thorough review.

5 | After the Exam

  • Save results for renewal portfolio.
  • Join ACRP community for networking.
  • Track CE credits early.

Key Takeaway

A consistent, structured plan + active practice + GCP mastery = success.

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